28.4104, FYI: Online Lecture: ''Primary Progressive Aphasia''

Fri Oct 6 17:05:28 UTC 2017

LINGUIST List: Vol-28-4104. Fri Oct 06 2017. ISSN: 1069 - 4875.

Subject: 28.4104, FYI: Online Lecture: ''Primary Progressive Aphasia''

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Date: Fri, 06 Oct 2017 13:05:13
From: Dirk Den Ouden [denouden at sc.edu]
Subject: Online Lecture: ''Primary Progressive Aphasia''

Thursday, October 12th, 2pm EDT
https://global.gotomeeting.com/join/667426173
http://cstar.sc.edu/lecture-series/

Lessons from studying behavioral and neural effects of transcranial direct
current stimulation in primary progressive aphasia
Kyrana Tsapkini, Ph.D, Johns Hopkins University

Transcranial direct current stimulation (tDCS)—a non-invasive technique that
is easy to implement by trained clinicians—has been increasingly shown to be a
valuable adjunct to speech and language therapy in stroke rehabilitation and
recently in primary progressive aphasia (PPA), a neurodegenerative syndrome
where language deficits are the first and foremost symptoms. Most studies in
the field, however, report tDCS effects on small sample sizes (1-8
participants) in underpowered designs and analyses that usually include only
one of the three PPA variants. I will present on the state-of-the science in
neuromodulation approaches in PPA. I will also present the results of a large
cohort of PPA participants treated under the same stimulation protocol. We
tested the additive effects of 15 sessions of anodal tDCS over the left IFG (a
main language production area) coupled with written language
production/spelling therapy, in a sham-controlled, double-blind,
within-subjects crossover design. Overall, tDCS was more effective than
language therapy alone (sham): therapy gains lasted longer (up to 2 months)
and generalized to untrained items. There were, however, differential effects
of tDCS in each variant. Finally, we evaluated which brain areas may predict
therapy outcomes. From all areas tested, only the volumes of the left
hippocampus and the left fusiform predicted performance on trained and
untrained items in writing/spelling. Finally, I will present some data on the
mechanisms of tDCS over the left IFG looking at changes in functional
connectivity using resting-state fMRI and changes in the inhibitory
neurotransmitter GABA using magnetic resonance spectroscopy (MRS). 

The lecture will be held at Johns Hopkins University. However, it will be
broadcast live.

Viewing event at the University of South Carolina:
Room #140, Discovery I, 915 Greene Street, Columbia, SC 29208
Date: Thursday, October 12, Time: 2pm – 3pm EDT
The viewing event will be catered!

The lecture can also be followed online from your computer, tablet or
smartphone, via the following GoToMeeting address (no password required):
https://global.gotomeeting.com/join/667426173

You can also dial in using your phone. 
United States : +1 (872) 240-3412
Access Code: 667-426-173
First GoToMeeting? Try a test session: http://help.citrix.com/getready

C-STAR Lecture Series:

The Center for the Study of Aphasia Recovery (C-STAR;
http://cstar.sc.edu/lecture-series/) houses researchers who examine the
effects of behavioral treatment, brain stimulation, and residual brain
function (brain plasticity) on recovery from aphasia. C-STAR is a
collaboration between researchers from the University of South Carolina, the
Medical University of South Carolina, Johns Hopkins University, and the
University of California, Irvine. The Center is funded through the National
Institute of Deafness and Communication Disorders (NIDCD) grant #NIH P50
DC014664. Biweekly public lectures, given by members and guests of C-STAR, are
accessible live and online. Recordings of the lectures can be viewed via
C-STAR YouTube channel:
https://www.youtube.com/channel/UC8p0CuG4He9nqCR4nnzhZ7w

For more information, please contact:

Dirk-Bart den Ouden, Ph.D.
Associate Professor, Communication Sciences and Disorders
Neurolinguistics Lab | http://www.mccauslandcenter.sc.edu/den_ouden/
University of South Carolina | Arnold School of Public Health
Discovery I Building, Office 202 C
915 Greene Street, Columbia, SC 29208
Tel. 803-777-9241 (office) | Email: denouden at sc.edu

Linguistic Field(s): Applied Linguistics
                     Cognitive Science
                     Neurolinguistics
                     Phonology
                     Psycholinguistics
                     Semantics

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