29.1831, FYI: Online Lecture, 5/3: tDCS and aphasia treatment

[The LINGUIST List]

LINGUIST List: Vol-29-1831. Mon Apr 30 2018. ISSN: 1069 - 4875.

Subject: 29.1831, FYI:  Online Lecture, 5/3: tDCS and aphasia treatment

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Date: Mon, 30 Apr 2018 14:01:29
From: Dirk Den Ouden [denouden at sc.edu]
Subject: Online Lecture, 5/3: tDCS and aphasia treatment

 
Thursday, May 3rd, 2pm ET
https://global.gotomeeting.com/join/667426173
http://cstar.sc.edu/lecture-series/
 
Effects of tDCS on Aphasia Treatment Outcomes: A Clinical Trial
Julius Fridriksson, PhD, CCC-SLP
University of South Carolina
 
Aphasia is a debilitating language disorder for which behavioral speech
therapy is the most efficient treatment, but therapy outcomes are variable and
full recovery is not always achieved. It remains unclear if adjunctive brain
stimulation (anodal [A]-tDCS) applied during aphasia therapy can improve
outcome. We tested whether it is futile to study A-tDCS as an adjunctive
intervention during speech therapy to improve speech production (naming) for
subjects with chronic post-stroke aphasia. This was a double-blinded,
prospective, randomized, controlled, clinical trial employing a futility
design to test adjunctive A-tDCS during speech therapy. The study enrolled 74
patients with chronic (>6 months) aphasia due to one previous left hemisphere
stroke. In comparing A-tDCS and sham tDCS, patients were matched based on site
(University of South Carolina or Medical University of South Carolina),
baseline age, type of aphasia and aphasia severity. All participants underwent
aphasia treatment for 3-weeks (15 sessions; 45 minutes each) combined with
either A-tDCS vs. sham tDCS applied to preserved left temporal lobe regions.
The primary outcome was the ability to name common objects, assessed twice
before and after therapy. The adjusted mean change from pre-treatment baseline
in correct naming was 13.9 words (95% CI: 9.0, 18.7) for A-tDCS and 8.2 words
(95% CI: 3.8, 12.6) for sham tDCS, with mean A-tDCS difference of 5.7 words
(95% CI:  -0.9 - 12.3), indicating a 70% increase in correct naming for A-tDCS
relative to sham. The futility hypothesis p-value was 0.896, indicating
failure to reject the null hypothesis, and, therefore, providing no evidence
that further study of anodal tDCS is futile. We also completed one-tailed
superiority analyses (A-tDCS>S-tDCS), which revealed greater overall
improvement in naming associated with A-tDCS over S-tDCS for both trained
(t=2.35, p=.011) and untrained items, (t=1.74, p=.044). Finally, the effects
of BDNF genotype on treatment outcome were studied. Our findings provide
evidence that A-tDCS may improve the outcome of aphasia treatment and motivate
further study in this area.
_______________________________________________
This lecture will be held at the University of South Carolina:
Room #140, Discovery I, 915 Greene Street, Columbia, SC 29208
Date: Thursday, May 3rd, Time: 2pm – 3pm Eastern Time
The event will be catered!
 
The lecture can also be followed online from your computer, tablet or
smartphone, via the following GoToMeeting address (no password
required):https://global.gotomeeting.com/join/667426173
 
You can also dial in using your phone.
United States : +1 (872) 240-3412
Access Code: 667-426-173
First GoToMeeting? Try a test session: http://help.citrix.com/getready

More information:
Dirk-Bart den Ouden, Ph.D.
Dept. of Communication Sciences and Disorders
University of South Carolina
Tel. 803-777-9241 (office)
Email: denouden at sc.edu
 



Linguistic Field(s): Clinical Linguistics
                     Neurolinguistics





 



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